Microbial community-scale metabolic modelling predicts personalized short-chain fatty acid production profiles in the human gut

2024/06/24 by Nick Quinn-Bohmann, Tomasz Wilmanski, Katherine Ramos Sarmiento +8 · 1 voice · 9 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Diet and metabolism studies #Diet, Metabolism, and Disease #Gut microbiota and health

paper · doi:10.1038/s41564-024-01728-4

crossref issued 2024/06/24 · crossref published 2024/06/24 · crossref published-online 2024/06/24 · openalex publication_date 2024/06/24 · crossref created 2024/06/24 · crossref deposited 2024/07/03 · openalex created_date 2025/10/10 · crossref indexed 2026/07/25 · openalex updated_date 2026/07/25

Citations

• The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication
• Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity
• Gut microbiota-derived metabolites as central regulators in metabolic disorders
• Gut-microbiota-targeted diets modulate human immune status

Cited by

• Moving from genome-scale to community-scale metabolic models for the human gut microbiome
• Genome-scale metabolic models predict diet- and lifestyle-driven shifts of ecological interactions in the gut microbiome
• Distinguishing the causative, correlative and bidirectional roles of the gut microbiota in mental health
• Clinical translation of microbiome research
• Culturing microbiome therapeutics with big data
• Resource sharing of an infant gut microbiota synthetic community in combinations of human milk oligosaccharides
• My Digital Gut: a tool set for microbiome-mediated precision nutrition - Pacific event
• Understanding disease-associated metabolic changes in human colonic epithelial cells using the iColonEpithelium metabolic reconstruction
• Distinct compositional changes but shared quantitative microbiome and anti-inflammatory modulations by diet
• Personalized Clostridioides difficile colonization risk prediction and probiotic therapy assessment in the human gut

Discussions

• In July, Nick's precision nutrition paper was the cover article in Nature Microbiology (cover attached). Nick showed that microbial community-scale metabolic models (MCMMs) could be used to predict pe [bsky, 4 points, 1 comments]