Personalized Clostridioides difficile colonization risk prediction and probiotic therapy assessment in the human gut

2025/08/01 by Alex V. Carr, Nitin S. Baliga, Christian Diener +1 · 2 voices
Biochemistry, Genetics and Molecular Biology · Medicine · #Clostridium difficile and Clostridium perfringens research #Gastrointestinal motility and disorders #Gut microbiota and health

paper · doi:10.1016/j.cels.2025.101367

crossref issued 2025/08/01 · crossref published 2025/08/01 · crossref published-print 2025/08/01 · openalex publication_date 2025/08/01 · crossref created 2025/08/06 · openalex created_date 2025/10/10 · crossref deposited 2025/11/08 · crossref indexed 2026/07/10 · openalex updated_date 2026/07/11

Citations

• UMAP: Uniform Manifold Approximation and Projection for Dimension Reduction
• Gut microbiota in human metabolic health and disease
• Personalized Nutrition by Prediction of Glycemic Responses
• Microbial community-scale metabolic modelling predicts personalized short-chain fatty acid production profiles in the human gut

Discussions

• A microbial community-scale metabolic model predicts C. difficile colonization risk & probiotic response in gut communities. Clinicians dreamed about this for a long time! @gibbological.bsky.social an [bsky, 4 points, 0 comments]
• Also, Bacteroides/Phocaeicola were negatively correlated with colonization, very similar to what we found in our microbial-community-scale metabolic models: doi.org/10.1016/j.ce... [bsky, 2 points, 0 comments]