2025/03/27 by Mohsen Meidani, Maryam Moradi, Mehrzad Rahmanian +7 · 1 voice
Medicine · #Actinomycetales infections and treatment #Antifungal resistance and susceptibility #Infective Endocarditis Diagnosis and Management
paper · doi:10.1093/ofid/ofaf198
openalex publication_date 2025/03/27 · openalex created_date 2025/04/04 · openalex updated_date 2026/07/29
Abstract Introduction Fungal endocarditis is a very uncommon and deadly illness that causes inflammation in the heart's lining, including the valves. Aspergillus endocarditis is the second most common cause of prosthetic endocarditis, especially the aortic valve, after Candida spp. Aspergillus endocarditis can occur on native and prosthetic valves, even in immunocompetent hosts. Case Report In this article, we describe a case of recurrent aortic-valve Aspergillus endocarditis occurring in a Caucasian man without previously known immunocompromised status with multiple brain septic emboli and spondylodiscitis. The patient was successfully responsive to liposomal amphotericin B. Discussion Early recognition in patients with underlying immunosuppressive conditions and immunocompetent hosts is critical to decreasing the mortality rate. Aspergillosis must be considered in every patient with a prior valve replacement history and culture-negative endocarditis. Surgical debridement and appropriate antifungal agents are required to resolve the problem.