2026/01/01 by William Kazunori Sekiguchi, Juliana Possatto Fernandes Takahashi, Jessica de Brito Ferreira Nascimento +9 · 1 voice
Biochemistry, Genetics and Molecular Biology · Medicine · #Antifungal resistance and susceptibility #Fungal Infections and Studies #Fungal and yeast genetics research
paper · doi:10.1590/1678-9199-jvatitd-2025-0091
openalex publication_date 2026/01/01 · openalex created_date 2026/06/05 · openalex updated_date 2026/06/13
Abstract Background: Central nervous system aspergillosis is a rare and severe condition with high mortality and frequent diagnostic delay. Infection due to Aspergillus penicillioides in this setting is rarely reported. Case presentation: We describe a rare case of cerebral infection caused by A. penicillioides in an immunocompetent patient, initially mistaken for a schwannoma. Histopathological examination revealed hyaline septate hyphae, and molecular analysis of formalin-fixed and paraffin-embedded (FFPE) tissue supported the identification by sequencing of a fragment of the 28S rRNA gene. Following an initial surgical resection, clinical deterioration ensued, necessitating a repeat procedure and targeted antifungal therapy, which ultimately led to disease stabilization and outpatient discharge. Conclusion: This case highlights the diagnostic difficulties and therapeutic challenges posed by rare Aspergillus species in immunocompetent hosts.