Mitochondrial TCA cycle metabolites control physiology and disease

2020/01/03 by Inmaculada Martínez‐Reyes, Navdeep S. Chandel · 33 citations
Biochemistry, Genetics and Molecular Biology · #ATP Synthase and ATPases Research #Cancer, Hypoxia, and Metabolism #Mitochondrial Function and Pathology

paper · pdf · doi:10.1038/s41467-019-13668-3

openalex publication_date 2020/01/03 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30

Abstract

Mitochondria are signaling organelles that regulate a wide variety of cellular functions and can dictate cell fate. Multiple mechanisms contribute to communicate mitochondrial fitness to the rest of the cell. Recent evidence confers a new role for TCA cycle intermediates, generally thought to be important for biosynthetic purposes, as signaling molecules with functions controlling chromatin modifications, DNA methylation, the hypoxic response, and immunity. This review summarizes the mechanisms by which the abundance of different TCA cycle metabolites controls cellular function and fate in different contexts. We will focus on how these metabolites mediated signaling can affect physiology and disease.

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