Succinate aggravates pulmonary fibrosis through the succinate/SUCNR1 axis

2025/03/27 by Rishi Rajesh, Agnes A. Mooslechner, Hanna Schweighöfer +11 · 1 voice
Medicine · #Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis #Pulmonary Hypertension Research and Treatments #Chronic Obstructive Pulmonary Disease (COPD) Research

paper · pdf · doi:10.1152/ajplung.00286.2024

openalex publication_date 2025/03/27 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28

Abstract

This paper highlights the role of the succinate/SUCNR1 axis in pulmonary fibrosis. Receptor activation leads to profibrotic changes in IPF patient-derived fibroblasts. This finding could also be replicated in a mouse model of pulmonary fibrosis.

Citations

• Mitochondrial TCA cycle metabolites control physiology and disease
• Idiopathic pulmonary fibrosis: Disease mechanisms and drug development

Discussions

• Happy to share a recent article from our group on the pro-fibrotic effect of succinate receptor activation in #IPF. Grateful to the entire team without whom this would not have been possible!! doi.org [bsky, 0 points, 0 comments]