Metabolic reprogramming in macrophages and dendritic cells in innate immunity

2015/06/05 by Beth Kelly, Luke O'neill, Luke AJ O'Neill · 11 citations
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · #Cancer, Hypoxia, and Metabolism #Immune Cell Function and Interaction #Immune cells in cancer

paper · pdf · doi:10.1038/cr.2015.68

openalex publication_date 2015/06/05 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30

Abstract

Activation of macrophages and dendritic cells (DCs) by pro-inflammatory stimuli causes them to undergo a metabolic switch towards glycolysis and away from oxidative phosphorylation (OXPHOS), similar to the Warburg effect in tumors. However, it is only recently that the mechanisms responsible for this metabolic reprogramming have been elucidated in more detail. The transcription factor hypoxia-inducible factor-1α (HIF-1α) plays an important role under conditions of both hypoxia and normoxia. The withdrawal of citrate from the tricarboxylic acid (TCA) cycle has been shown to be critical for lipid biosynthesis in both macrophages and DCs. Interference with this process actually abolishes the ability of DCs to activate T cells. Another TCA cycle intermediate, succinate, activates HIF-1α and promotes inflammatory gene expression. These new insights are providing us with a deeper understanding of the role of metabolic reprogramming in innate immunity.

Citations

• THE METABOLISM OF TUMORS IN THE BODY

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