THE METABOLISM OF TUMORS IN THE BODY

1927/03/07 by Otto Warburg, Otto Warbürg, Franz Wind +1 · 27 citations
Medicine · #Neuroblastoma Research and Treatments

paper · pdf · doi:10.1085/jgp.8.6.519

Abstract

In this contribution we discuss the question of whether tumor cells in living animals can be killed off through lack of energy, and the related question of how the tumors are supplied with oxygen and glucose in the body.

Cited by

• Mitochondrial metabolism as a pharmacological target for cancer therapeutics
• Orchestrating glucose metabolism: PFKFB2 as a signal-integrating conductor in homeostasis and disease
• Discovery of First-in-Class Carbonic Anhydrase/Histone Deacetylase Dual Inhibitors with Antiproliferative Activity in Cancer Cells
• The Warburg effect: 80 years on
• Cancer-associated fibroblasts: a versatile mediator in tumor progression, metastasis, and targeted therapy
• Targeting succinylation-mediated metabolic reprogramming as a potential approach for cancer therapy
• Successful application of dietary ketogenic metabolic therapy in patients with glioblastoma: a clinical study
• Acidosis Forces Fatty Acid Uptake and Metabolism in Cancer Cells Regardless of Genotype
• Thermal resonance in cancer
• The multifaceted roles of mitochondria at the crossroads of cell life and death in cancer
• Metabolic reprogramming in macrophages and dendritic cells in innate immunity
• Design, synthesis and biological evaluation of naphthalene-1,4-dione analogues as anticancer agents
• <i>Porphyromonas gingivalis</i> ‐Lipopolysaccharide Induced Gingival Fibroblasts Trained Immunity Sustains Inflammation in Periodontitis
• The role of GAPDH in the selective toxicity of CNP in melanoma cells
• Spatial heterogeneity of lactylation: insights into gene expression, metabolism, and lactate transport in human embryonic stem cells
• Bi-Polar Bioenergetic Intervention via a Pathology Self-Adaptive Single-Atom Nanocatalyst for Diabetic Tumor Postoperative Management
• Coupling of ATP and PMF in <i>Escherichia coli</i> is determined by growth conditions
• The role of fibroblast growth factors in cell and cancer metabolism
• Development and Validation of a Carbohydrate Metabolism-Related Model for Predicting Prognosis and Immune Landscape in Hepatocellular Carcinoma Patients
• The hallmarks of cancer metabolism: Still emerging
• Metabolic reprogramming in macrophage responses
• tRNA-derived fragment tRFLys-CTT-010 promotes triple-negative breast cancer progression by regulating glucose metabolism via G6PC
• The Warburg effect: The hacked mitochondrial-nuclear communication in cancer
• Upregulated hexokinase 2 expression induces the apoptosis of dopaminergic neurons by promoting lactate production in Parkinson's disease
• Brain development and bioenergetic changes
• Deep learning framework integrating 18F-FDG PET/CT and clinical data for early prediction of chemotherapy response in advanced breast cancer
• Microfluidics [wikipedia]

Related

• The Warburg effect: 80 years on
• Balancing the cellular budget: lessons in metabolism from microbes to cancer
• Physiological properties of malignant tumours
• Tumor metabolism: cancer cells give and take lactate
• Comparison of Metabolic Pathways between Cancer Cells and Stromal Cells in Colorectal Carcinomas: a Metabolic Survival Role for Tumor-Associated Stroma