2021/09/30 by Hartwig, Andrea, MAK Commission
#Akkumulation #Analogiebetrachtung #Decyl (Z)-octadec-9-enoate #Decyl-(Z)-octadec-9-enoat #Entwicklungstoxizität #Lunge #MAK value #MAK-Wert #accumulation #developmental toxicity #lung #maximale Arbeitsplatzkonzentration #maximum concentration at the workplace #n-Decyloleat #n-decyl oleate #oleic acid n-decyl ester #read-across #Ölsäure-n-decylester
paper · doi:10.34865/mb368746kske6_3ad
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re-evaluated n-decyl oleate [3687-46-5], considering all toxicological end points. Available publications and unpublished study reports are described in detail. As with white mineral oil, inhalation of aerosols of the hardly water-soluble n-decyl oleate could result in overload in the lung, inflammatory reactions and microgranulomas. To prevent this overload, a maximum concentration at the workplace (MAK value) of 5 mg/m is derived for the respirable fraction by analogy with white mineral oil and Peak Limitation Category II as well as an excursion factor of 4 are set. There are no developmental toxicity studies and n-decyl oleate is assigned to Pregnancy Risk Group D. n-Decyl oleate is not genotoxic in bacteria. Carcinogenicity studies are not available. There are no indications of a contact sensitizing potential of n-decyl oleate in humans and in animal studies. Skin contact is not expected to contribute significantly to systemic toxicity.