2021/09/30 by Hartwig, Andrea, MAK Commission
#Akkumulation #Analogiebetrachtung #Entwicklungstoxizität #Fertilität #Isodecyloleat #Lunge #MAK value #MAK-Wert #accumulation #developmental toxicity #fertility #isodecyl oleate #lung #maximale Arbeitsplatzkonzentration #maximum concentration at the workplace #oleic acid isodecyl ester #read-across #Ölsäureisodecylester
paper · doi:10.34865/mb5923134kske6_3ad
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re-evaluated isodecyl oleate [59231-34-4], considering all toxicological endpoints. Available publications and unpublished study reports are described in detail. As with white mineral oil, inhalation of aerosols of the hardly water-soluble isodecyl oleate could result in overload in the lung, inflammatory reactions and microgranulomas. To prevent this overload, a MAK value of 5 mg/m is derived for the respirable fraction by analogy with white mineral oil and Peak Limitation Category II as well as an excursion factor of 4 are set. A NOAEL for developmental effects is 300 mg/kg body weight and day after oral treatment of rats but no teratogenicity was examined and isodecyl oleate is assigned to Pregnancy Risk Group D. Isodecyl oleate is not genotoxic in bacteria. Carcinogenicity studies carried out according to the test guidelines are not available. There are no indications of a contact sensitizing potential of isodecyl oleate. Skin contact is not expected to contribute significantly to systemic toxicity.