2022/03/31 by Hartwig, Andrea, MAK Commission
#(Z)-9-Octadecensäure-2-ethylhexylester #2-Ethylhexyl-(Z)-octadec-9-enoat #2-Ethylhexyl-9-octadecenoat #2-Ethylhexyoleat #2-ethylhexyl oleate #Aerosol #Analogiebetrachtung #Entwicklungstoxizität #Entzündung #Lungentoxizität #MAK value #MAK-Wert #Mikrogranulom #aerosol #developmental toxicity #inflammation #lung toxicity #maximale Arbeitsplatzkonzentration #maximum workplace concentration #microgranuloma #overload #read-across #Ölsäure-2-ethylhexylester #Überladungseffekt
paper · doi:10.34865/mb2639902kskd7_1or
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated 2-ethylhexyl oleate [26399-02-0] to derive a maximum concentration at the workplace (MAK value), considering all toxicological endpoints. Available publications are described in detail. As with white mineral oil, inhalation of aerosols of the hardly water-soluble 2-ethylhexyl oleate could result in overload in the lung, inflammatory reactions and microgranulomas. To prevent this overload, a MAK value of 5 mg/m3 for the respirable fraction is established by analogy with white mineral oil and Peak Limitation Category II as well as an excursion factor of 4 is set. The classification in Pregnancy Risk Group D is given because developmental toxicity studies are lacking. 2-Ethylhexyl oleate is not genotoxic. Carcinogenicity studies are not available. There are no indications of a sensitizing potential of 2-ethylhexyl oleate. Skin contact is not expected to contribute significantly to systemic toxicity.