Caenorhabditis Intervention Testing Program: all-trans retinoic acid-related compounds tamibarotene and bakuchiol do not extend lifespan in Caenorhabditis nematodes

2025/01/21 by Stephen A. Banse, Anna L Coleman-Hulbert, Christine A. Sedore +4
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #Bioactive natural compounds #Biological and pharmacological studies of plants #Synthesis of Indole Derivatives

paper · doi:10.17912/micropub.biology.001517

openalex publication_date 2025/01/21 · openalex created_date 2025/03/05 · openalex updated_date 2026/07/01

Abstract

, showed no significant increase in lifespan across a dosage range of six concentrations. Additionally, bakuchiol was broadly toxic at higher doses. These findings highlight the specificity of atRA's longevity effects and suggest that compounds related to atRA may not universally promote lifespan extension.

Citations

• Prospective, randomized, double‐blind assessment of topical bakuchiol and retinol for facial photoageing

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