Screening for toxicity of azole fungicides in Caenorhabditis elegans identifies triflumizole as a potent reproductive and developmental toxicant

2025/07/18 by Samantha Hughes, C. J. Koopmans, Majorie B.M. van Duursen
Agricultural and Biological Sciences · Biochemistry, Genetics and Molecular Biology · #Carcinogens and Genotoxicity Assessment #Genetically Modified Organisms Research #Pesticide Exposure and Toxicity

paper · doi:10.17912/micropub.biology.001755

openalex publication_date 2025/07/18 · openalex created_date 2025/09/04 · openalex updated_date 2026/07/01

Abstract

may provide insights into the broader impact of azole fungicides relevant to human health. Exposure to triflumizole, resulted in a significant reduction in brood size as well as a dose-dependent decrease in worm development. Similarly, clotrimazole negatively impacted development, but not reproduction, while ketoconazole had no detrimental effect. Together this suggests further research is urgently needed to explore the impact of azole chemicals on human reproductive health.

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