2025/09/19 by Randy Strong, James F. Nelson, Molly A. Bogue +31 · 1 voice · 2 citations
Biochemistry, Genetics and Molecular Biology · Neuroscience · #Circadian rhythm and melatonin #Genetics, Aging, and Longevity in Model Organisms #Neuroinflammation and Neurodegeneration Mechanisms
paper · pdf · doi:10.1007/s11357-025-01881-6
openalex publication_date 2025/09/19 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/29
Mice bred in 2021 were tested by the Interventions Testing Program (ITP) for possible lifespan benefits of 2BAct (2BA), dichloroacetate (DCA), Epicatechin (EPI), Forskolin (FSK), Halofuginone (HAL) and Mitoglitazone (MIT). All agents were administered in the diet ad libitum beginning at 7 months of age. In male mice, EPI increased median lifespan by ~ 5%, and HAL and MIT each increased median lifespan by ~ 9%. EPI and HAL, but not MIT, increased 90% survival. In addition to adding 3 new agents to the list of interventions identified by the ITP that extend lifespan, this report continues the strong male bias in the efficacy of life-extending drugs identified so far.