2025/01/01 by Hartwig, Andrea, MAK Commission
Biochemistry, Genetics and Molecular Biology · Environmental Science · Medicine · #571.95 Toxicology #571.95 Toxikologie #616.9803 Betriebs- und Arbeitsmedizin #616.9803 Industrial and occupational medicine #Aminocyclohexan #Aminocyclohexane #Aminohexahydrobenzene #Aminohexahydrobenzol #Carcinogens and Genotoxicity Assessment #Cyclohexanamin #Cyclohexanamine #Cyclohexylamin #Cyclohexylamine #Hexahydroanilin #Hexahydroaniline #Indoor Air Quality and Microbial Exposure #Luft #MAK value #MAK-Wert #Momentanwert #Occupational exposure and asthma #Reizwirkung #Spitzenbegrenzung #air #ceiling limit value #irritation #maximale Arbeitsplatzkonzentration #maximum workplace concentration #momentary value #peak limitation
paper · doi:10.34865/mb10891e6218_w
openalex publication_date 2025/01/01 · openalex created_date 2025/12/13 · openalex updated_date 2026/07/01
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the maximum concentration at the workplace (MAK value) for cyclohexylamine. A 4‐hour inhalation study with volunteers showed clear irritation at 10 ml/m3, whereas a time‐weighted average concentration of 2 ml/m3 with peaks of up to 4 ml/m3 was without impact on sensory irritation parameters and neurobehavioral measurements. The MAK value of 2 ml/m3 and classification in Peak Limitation Category I has been retained. No irritation was observed up to 4 ml/m3; therefore, the excursion factor 2 has been retained as well. As cyclohexylamine is a strong base and 10 ml/m3 is clearly irritating, a momentary value of 5 ml/m3 is set. Completed: April 20, 2016: