2025/01/01 by Hartwig, Andrea, MAK Commission
Biochemistry, Genetics and Molecular Biology · Environmental Science · Medicine · #571.95 Toxicology #571.95 Toxikologie #616.9803 Betriebs- und Arbeitsmedizin #616.9803 Industrial and occupational medicine #Carcinogens and Genotoxicity Assessment #DEA #Diethylamin #Diethylamine #Hautresorption #Indoor Air Quality and Microbial Exposure #Luft #MAK value #MAK-Wert #Momentanwert #N-Ethylethanamin #N-Ethylethanamine #Occupational exposure and asthma #Reizwirkung #Spitzenbegrenzung #air #ceiling limit value #irritation #maximale Arbeitsplatzkonzentration #maximum workplace concentration #momentary value #olfactory epithelium #olfaktorisches Epithel #peak limitation #skin absorption
paper · doi:10.34865/mb10989e6018_w
openalex publication_date 2025/01/01 · openalex created_date 2025/12/13 · openalex updated_date 2026/07/01
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated the maximum concentration at the workplace (MAK value) of diethylamine of 5 ml/m3, considering all toxicity endpoints. Available unpublished study reports and publications are described in detail. The critical effect of diethylamine is atrophy of the olfactory mucosa in rats and mice in a 2‐year study. Since 2014 the Commission uses an empirical approach to set MAK values for substances with critical effects on the upper respiratory tract or the eyes. In the 2‐year study no NOAEC for atrophy of the olfactory mucosa was obtained. A Benchmark concentration of 4 ml/m3 (BMDL05) as a substitute for a NOAEC is calculated from the data of the mouse, the most sensitive species. Therefore, the MAK value for diethylamine is lowered to 2 ml/m3. The chronic NOAEC for systemic toxicity is judged to be 16 ml/m3. As local effects are critical, the assignment to Peak Limitation Category I is confirmed. The excursion factor of 2 is set with a read‐across to cyclohexylamine. The momentary value is lowered to 5 ml/m3. Because there are no studies on developmental toxicity, the assignment to Pregnancy Risk Group D is confirmed as well. Diethylamine is not genotoxic and not carcinogenic. Skin contact may contribute significantly to systemic toxicity and diethylamine is designated with an “H” notation. Sensitization is not expected from the limited data.