2022/06/29 by Hartwig, Andrea, MAK Commission
#Aminomethan #Entwicklungstoxizität #Gefahrstoff #MAK value #MAK-Wert #Methanamin #Methylamin #Momentanwert #Nase #Reizwirkung #Toxizität #aminomethane #developmental toxicity #hazardous substance #irritation #maximale Arbeitsplatzkonzentration #maximum workplace concentration #methanamine #methylamine #momentary value #nose #toxicity
paper · doi:10.34865/mb7489e7_2ad
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re-evaluated methylamine [74-89-574-89-5]. The critical effect is irritation of the nasal airways as observed in a 2-week study in rats with a NOAEC of 75 ml/m3. The RD50 data for methylamine show that its irritation potency is lower than that of other aliphatic amines with a MAK value of 2 ml/m3. Overall, a MAK value of 5 ml/m3 has been derived from these data. As the critical effect is local irritation, Peak Limitation Category I has been retained. An excursion factor of 2 has been set by analogy with trimethylamine and cyclohexylamine. For both amines, a momentary value (ceiling limit) was set at two times the MAK value. Therefore, the momentary value of 10 ml/m3 for methylamine has been retained. The NOAELs for developmental toxicity obtained in an oral screening study in rats (230 mg/kg body weight and day) and a teratogenicity study with i.p. application in mice (155 mg/kg body weight and day) are sufficiently high. Therefore, damage to the embryo or foetus is unlikely when the MAK value is not exceeded and methylamine is classified in Pregnancy Risk Group C. Methylamine is not genotoxic. Carcinogenicity studies are not available. According to calculations, methylamine is not taken up via the skin in amounts that can induce systemic effects. There are no data that show that methylamine is a skin or airway sensitizer.