2024/09/29 by Hartwig, Andrea, MAK Commission
#2-Diethylaminoethanol #571.95 Toxicology #571.95 Toxikologie #616.9803 Betriebs- und Arbeitsmedizin #616.9803 Industrial and occupational medicine #Entwicklungstoxizität #Luft #MAK value #MAK-Wert #Momentanwert #N #N-Diethylethanolamin #N-Diethylethanolamine #Reizwirkung #air #developmental toxicity #irritation #maximale Arbeitsplatzkonzentration #maximum workplace concentration #momentary value #oberer Respirationstrakt #upper respiratory tract
paper · doi:10.34865/mb10037e9_3ad
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area (MAK Commission) has re-evaluated the occupational exposure limit value (maximum concentration at the workplace, MAK value) and the pregnancy risk group of 2-diethylaminoethanol [100-37-8] considering also irritating and sensitizing effects. Relevant studies were identified from a literature search. The critical effect of 2-diethylaminoethanol is the local effect on the upper respiratory tract. There are no human data to derive a MAK value. In a 14-week inhalation study with rats already reported in the evaluation from 2007, the lowest concentration of 11 ml/m3 is the NOAEC resulting in a MAK value of 2 ml/m3. Since a local effect is critical, Peak Limitation Category I is retained. As data on humans are missing, an excursion factor of 1 and in analogy to other amines with a MAK value of 2 ml/m3, a momentary value of 5 ml/m3 is set. In a developmental toxicity study in rats reported in the evaluation from 2007, the highest concentration of 100 ml 2-diethylaminoethanol/m3 corresponds to the NOAEC. There are no new data on developmental toxicity. Considering the increased respiratory volume at the workplace there is a 25-fold margin to the MAK value. Thus, Pregnancy Risk Group C has been retained for 2-diethylaminoethanol. There are no data showing a skin sensitizing potential in humans or animals. Data investi-gating respiratory sensitization are missing. According to skin absorption models, 2-diethylaminoethanol is not expected to be taken up via the skin in toxicologically relevant amounts and is thus no longer designated with “H”.