2014/08/29 by Mohammad Asif, Asif, Mohammad
Chemistry · #Heterocyclic compound #Synthesis and Characterization of Heterocyclic Compounds #Synthesis and Reactions of Organic Compounds #Synthesis and biological activity #biological activities #chemistry #synthesis. #thiadiazole
paper · doi:10.48317/imist.prsm/morjchem-v2i4.2136
openalex publication_date 2014/08/29 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/01
The thiadiazole is one of the most important and well-known five-membered heterocyclic nuclei, which is a common and integral feature of a variety of natural products and medicinal agents. Thiadiazole nucleus is present as a core structural component in an array of drug categories such as antimicrobial, anti-inflammatory, analgesic, antiepileptic, antiviral, antineoplastic, and antitubercular agents. The activity of thiadiazole derivatives has established them as pharmacologically significant scaffolds. The structural modifications of thiadiazole rings with different atoms or groups cause various pharmacological activities. Chemical properties of 1,3,4-thiadiazole have been reviewed in the last few years. However, the usefulness of 1,3,4-thiadiazole as a privileged system in medicinal chemistry has prompted the advances on the therapeutic potential of this system. This review provides a brief summary of the medicinal chemistry of 1,3,4-thiadiazole system and highlights some examples of 1,3,4-thiadiazole-containing drug substances in the current literature. A survey of representative literature procedures for the preparation of 1,3,4-thiadiazole is presented in sections by generalized synthetic methods