Hyperuricemia enhances intracellular urate accumulation via down-regulation of cell-surface BCRP/ABCG2 expression in vascular endothelial cells
2018/01/06 by Hisakazu Komori, Kazuyuki Yamada, Ikumi Tamai · 25 citations
Chemistry · Medicine · #ATP-binding cassette transporter #Abcg2 #Alcohol Consumption and Health Effects #Biochemistry #Biology #Bone and Joint Diseases #Chemistry #Endocrinology #Endothelial dysfunction #Gout, Hyperuricemia, Uric Acid #Hyperuricemia #Internal medicine #Medicine #NADPH oxidase #Oxidative stress #Transporter #Uric acid
paper · doi:10.1016/j.bbamem.2018.01.006
openalex publication_date 2018/01/06 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/25
Cited by
- Impaired arterial responsiveness in untreated gout patients compared with healthy non-gout controls: association with serum urate and C-reactive protein. [europepmc]
- Probiotic supplements prevented oxonic acid-induced hyperuricemia and renal damage. [europepmc]
- Changes of drug pharmacokinetics mediated by downregulation of kidney organic cation transporters Mate1 and Oct2 in a rat model of hyperuricemia. [europepmc]
- Cellular Processing of the ABCG2 Transporter-Potential Effects on Gout and Drug Metabolism. [europepmc]
- Research Advances in the Mechanisms of Hyperuricemia-Induced Renal Injury. [europepmc]
- Endothelial dysfunction in neuroprogressive disorders-causes and suggested treatments. [europepmc]
- Transport Properties of Statins by Organic Anion Transporting Polypeptide 1A2 and Regulation by Transforming Growth Factor- β Signaling in Human Endothelial Cells. [europepmc]
- Function of Multidrug Resistance Transporters is Disrupted by Infection Mimics in Human Brain Endothelial Cells. [europepmc]
- Network Pharmacology-Based Investigation of the Mechanism of Action of Plantaginis Herba in Hyperuricemia Treatment. [europepmc]
- Multidrug efflux transporter ABCG2: expression and regulation. [europepmc]
- The effects of hyperuricemia on endothelial cells are mediated via GLUT9 and the JAK2/STAT3 pathway. [europepmc]
- Impact of Uremic Toxins on Endothelial Dysfunction in Chronic Kidney Disease: A Systematic Review. [europepmc]
- The Interplay between Uremic Toxins and Albumin, Membrane Transporters and Drug Interaction. [europepmc]
- What If Not All Metabolites from the Uremic Toxin Generating Pathways Are Toxic? A Hypothesis. [europepmc]
- Differential gene expression of ABCG2, SLC22A12, IL-1β, and ALPK1 in peripheral blood leukocytes of primary gout patients with hyperuricemia and their comorbidities: a case-control study. [europepmc]
- Intracellular Metabolomics Identifies Efflux Transporter Inhibitors in a Routine Caco-2 Cell Permeability Assay-Biological Implications. [europepmc]
- Mechanism of PDZK1 in Hepatocellular Carcinoma Complicated with Hyperuricemia. [europepmc]
- Loss of the Kidney Urate Transporter, Urat1, Leads to Disrupted Redox Homeostasis in Mice. [europepmc]
- Self-Assembled nanoparticles Combining Berberine and Sodium Taurocholate for Enhanced Anti-Hyperuricemia Effect. [europepmc]
- Insights into the relationship between serum uric acid and pulmonary hypertension (Review). [europepmc]
- Effects of allopurinol and febuxostat on uric acid transport and transporter expression in human umbilical vein endothelial cells. [europepmc]
- Exploring the causal association between uric acid and lung cancer in east Asian and European populations: a mendelian randomization study. [europepmc]
- Gut commensal Parabacteroides distasonis exerts neuroprotective effects in acute ischemic stroke with hyperuricemia via regulating gut microbiota-gut-brain axis. [europepmc]
- Uric Acid and Atherosclerosis in Patients with Chronic Kidney Disease: Recent Progress, Mechanisms, and Prospect. [europepmc]
- Antihyperuricemic Effect of Hawthorn Flavonoid Vitexin: LC-MS Analysis, Network Pharmacology, and In Vivo Verification of Molecular Mechanisms. [europepmc]