2025/05/29 by Amber Yijia Zheng, Site Bai, Zheng, Amber Yijia +5 · 2 citations
Biochemistry, Genetics and Molecular Biology · Medicine · Social Sciences · #FOS: Computer and information sciences #Influenza Virus Research Studies #Machine Learning (cs.LG) #Vaccine Coverage and Hesitancy #vaccines and immunoinformatics approaches
paper · pdf · doi:10.48550/arxiv.2505.23760
openalex publication_date 2025/05/29 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
Model immunization aims to pre-train models that are difficult to fine-tune on harmful tasks while retaining their utility on other non-harmful tasks. Though prior work has shown empirical evidence for immunizing text-to-image models, the key understanding of when immunization is possible and a precise definition of an immunized model remain unclear. In this work, we propose a framework, based on the condition number of a Hessian matrix, to analyze model immunization for linear models. Building on this framework, we design an algorithm with regularization terms to control the resulting condition numbers after pre-training. Empirical results on linear models and non-linear deep-nets demonstrate the effectiveness of the proposed algorithm on model immunization. The code is available at https://github.com/amberyzheng/model-immunization-cond-num.