1997/06/01 by Dan Jones, David M. Dorfman, Raymond L. Barnhill +1 · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #Acute Myeloid Leukemia Research #Acute leukemia #Acute monocytic leukemia #Arteritis #Blood disorders and treatments #Chronic Lymphocytic Leukemia Research #Cutis #Disease #Immunology #Infiltration (HVAC) #Leukemia #Leukemia cutis #Medicine #Monocytic leukemia #Pathology #Vasculitis
paper · pdf · doi:10.1093/ajcp/107.6.637
openalex publication_date 1997/06/01 · openalex created_date 2016/06/24 · openalex updated_date 2026/07/30
Cutaneous involvement is common in certain subtypes of acute leukemia and may be a reflection of a capacity of these tumors for tissue infiltration. We have recently noted that leukemia cutis can be accompanied by vasculitis in a subset of patients. We describe six cases of such leukemic vasculitis with findings ranging from mild microvascular injury to necrotizing arteritis. All cases were seen in patients with acute leukemia with myelomonocytic or monocytic features. In one patient, cutaneous leukemic vasculitis represented the initial manifestation of leukemia. In most cases, leukemic infiltration of the dermal blood vessels was the predominant pattern of involvement with minimal dermal infiltration. Vascular injury seemed to be mediated by leukemic blasts and not by reactive inflammatory cells. We propose the term leukemic vasculitis to describe such lesions.