Multiple Hematoma, Purpura, and Ulcers in a Patient With Rheumatoid Arthritis

2025/08/01 by Saeko Yamada, Takanori Azuma · 1 voice
Medicine · #Case Reports on Hematomas #Heparin-Induced Thrombocytopenia and Thrombosis #Infectious Diseases and Tuberculosis

paper · pdf · doi:10.3899/jrheum.2025-0516

openalex publication_date 2025/08/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

Most biologics-associated cutaneous vasculitis cases involve tumor necrosis factor inhibitors, but here we report a case possibly induced by an interleukin (IL)-6 inhibitor, suggesting such autoimmune events may be underestimated. The patient, a 70-year-old female, suddenly presented with hematoma of multiple fingers while using tocilizumab (TCZ), a monoclonal antibody that targets the IL-6 receptor.

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