Calcineurin is a potent regulator for skeletal muscle regeneration by association with NFATc1 and GATA-2

2002/12/19 by Kunihiro Sakuma, Junji Nishikawa, Ryuta Nakao +5 · 12 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Biology #Calcineurin #Cardiac Structural Anomalies and Repair #Cell biology #Endocrinology #Internal medicine #Medicine #Muscle Physiology and Disorders #Muscle hypertrophy #Myocyte #Myogenesis #Myogenin #NFAT #Signaling Pathways in Disease #Skeletal muscle #Transplantation

paper · doi:10.1007/s00401-002-0647-0

openalex publication_date 2002/12/19 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/25

Cited by

• Cyclosporin A treatment upregulates Id1 and Smad3 expression and delays skeletal muscle regeneration
• Cyclosporin A modulates cellular localization of MEF2C protein and blocks fiber hypertrophy in the overloaded soleus muscle of mice
• Cholecystokinin activates pancreatic calcineurin-NFAT signaling in vitro and in vivo. [europepmc]
• G-protein coupled receptor 56 promotes myoblast fusion through serum response factor- and nuclear factor of activated T-cell-mediated signalling but is not essential for muscle development in vivo. [europepmc]
• Transcriptomic analysis of tail regeneration in the lizard Anolis carolinensis reveals activation of conserved vertebrate developmental and repair mechanisms. [europepmc]
• Cyclosporin A Promotes in vivo Myogenic Response in Collagen VI-Deficient Myopathic Mice. [europepmc]
• Calcium signaling in skeletal muscle development, maintenance and regeneration. [europepmc]
• Sarcolipin deletion exacerbates soleus muscle atrophy and weakness in phospholamban overexpressing mice. [europepmc]
• Vascular Delivery of Allogeneic MuStem Cells in Dystrophic Dogs Requires Only Short-Term Immunosuppression to Avoid Host Immunity and Generate Clinical/Tissue Benefits. [europepmc]
• Calmodulin-Binding Proteins in Muscle: A Minireview on Nuclear Receptor Interacting Protein, Neurogranin, and Growth-Associated Protein 43. [europepmc]
• p21-activated kinase 4 phosphorylates peroxisome proliferator-activated receptor Υ and suppresses skeletal muscle regeneration. [europepmc]
• Natural aging and ovariectomy induces parallel phosphoproteomic alterations in skeletal muscle of female mice. [europepmc]