2025/01/01 by Van Pul, Jan, Roßbach, Bernd, Göen, Thomas +2
Agricultural and Biological Sciences · Biochemistry, Genetics and Molecular Biology · Environmental Science · #(Propan-2-yl)benzen #(Propan-2-yl)benzol #1 #2-Dimethylbenzen #2-Dimethylbenzene #2-Dimethylbenzol #3-Dimethylbenzen #3-Dimethylbenzene #3-Dimethylbenzol #4-Dimethylbenzen #4-Dimethylbenzene #4-Dimethylbenzol #543 Analytical chemistry #543 Analytische Chemie #571.95 Toxicology #571.95 Toxikologie #616.9803 Betriebs- und Arbeitsmedizin #616.9803 Industrial and occupational medicine #Allgemeinbevölkerung #Analysen in biologischem Material #Analysenmethode #Analyses in Biological Materials #Arbeiter #Arbeitnehmer #Arbeitsplatz #Aromaten #BTX hydrocarbons #BTX-Aromaten #Benzen #Benzene #Benzol #Biomonitoring #Biomonitoringmethode #Carcinogens and Genotoxicity Assessment #Cumen #Cumene #Cumol #Dampfraum #Dimethylbenzen (alle Isomere) #Dimethylbenzene (all isomers) #Dimethylbenzol (alle Isomere) #Ethenylbenzen #Ethenylbenzene #Ethenylbenzol #Ethylbenzen #Ethylbenzene #Ethylbenzol #Fermentation and Sensory Analysis #HBM #HS-GC #HS-GC-MS #Headspace-Gaschromatographie mit Massenspektrometrie #Headspace-ITEX-GC-MS #Headspace-SPDE-GC-MS #Headspace‐GC‐MS #Hintergrundbelastung #Humanbiomonitoring #Indoor Air Quality and Microbial Exposure #Intoxikation #Isopropylbenzen #Isopropylbenzene #Isopropylbenzol #Methode #Methylbenzen #Methylbenzene #Methylbenzol #Phenylethen #Phenylethene #Styren #Styrene #Styrol #Toluen #Toluene #Toluol #Umweltbelastung #Urin #Vergiftung #Vinylbenzen #Vinylbenzene #Vinylbenzol #Xylen (alle Isomere) #Xylene (all isomeres) #Xylol (alle Isomere) #analytical method #aromatic compounds #aromatics #aromatische Verbindungen #background exposure #biological monitoring #biologisches Monitoring #biomonitoring #biomonitoring method #employee #environmental exposure #general population #headspace gas chromatography #headspace-ITEX-GC-MS #headspace-SPDE-GC-MS #headspace-gas chromatography with mass spectrometry #headspace‐GC‐MS #human biomonitoring #intoxication #m-Xylen #m-Xylene #m-Xylol #method #o-Xylen #o-Xylene #o-Xylol #p-Xylen #p-Xylene #p-Xylol #poisoning #urine #worker #workplace #workplace exposure
paper · doi:10.34865/bi7143d0022a_w
openalex publication_date 2025/01/01 · openalex created_date 2025/12/13 · openalex updated_date 2026/07/16
The working group „Analyses in Biological Materials“ of the Permanent Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area verified the presented biomonitoring method. The analytical method described hereinafter permits the simultaneous determination of the following unmetabolised aromatic compounds in urine: benzene, toluene, o‐xylene, m‐xylene, p‐xylene, ethylbenzene, styrene and isopropylbenzene (cumene). Prior to the determination of the analytes by GC‐MS, the analytes are extracted and enriched using ITEX (In Tube Extraction) or SPDE (Solid Phase Dynamic Extraction). To this end, the urine samples are incubated at 50 °C, the analytes extracted from the gas phase and then the enriched analytes are transferred to the gas chromatograph and analysed using mass spectrometry. Calibration standards are prepared in water and processed in the same way as the samples to be analysed. Deuterated benzene is used as internal standard. The method was extensively validated and the reliability data were confirmed by an independent laboratory, which has established and cross‐checked the whole procedure.