2015/03/16 by Md. Zubbair Malik, Shahnawaz Ali, Malik, Md. Zubbair +7
Biochemistry, Genetics and Molecular Biology · Medicine · #Cancer-related Molecular Pathways #Epigenetics and DNA Methylation #FOS: Biological sciences #Microtubule and mitosis dynamics #Molecular Networks (q-bio.MN) #Subcellular Processes (q-bio.SC) #q-bio.MN #q-bio.SC
paper · pdf · doi:10.48550/arxiv.1503.04732
arxiv created 2015/03/16 · openalex publication_date 2015/03/16 · arxiv updated 2015/03/17 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
We present the mechanism of interaction of Wnt network module, which is responsible for periodic sometogenesis, with p53 regulatory network, which is one of the main regulators of various cellular functions, and switching of various oscillating states by investigating p53-Wnt model. The variation in Nutlin concentration in p53 regulating network drives the Wnt network module to different states, stabilized, damped and sustain oscillation states, and even to cycle arrest. Similarly, the change in Axin concentration in Wnt could able to modulate the p53 dynamics at these states. We then solve the set of coupled ordinary differential equations of the model using quasi steady state approximation. We, further, demonstrate the change of p53 and Gsk3 interaction rate, due to hypothetical catalytic reaction or external stimuli, can able to regulate the dynamics of the two network modules, and even can control their dynamics to protect the system from cycle arrest (apoptosis).