2014/09/01 by Md. Jahoor Alam, Alam, Md. Jahoor, Shazia Kunvar +3
Biochemistry, Genetics and Molecular Biology · Chemistry · #Apoptosis #Artificial intelligence #Biochemistry #Chemistry #Computer science #Constant (computer programming) #Control (management) #Control theory (sociology) #Dynamics (music) #FOS: Biological sciences #Gene #Mdm2 #Mechanism (biology) #MicroRNA in disease regulation #Molecular Networks (q-bio.MN) #Oscillation (cell signaling) #Physics #Quantum mechanics #microRNA #q-bio.MN
paper · pdf · doi:10.48550/arxiv.1409.1943
arxiv created 2014/09/01 · openalex publication_date 2014/09/01 · arxiv updated 2014/09/09 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/06
The regulating mechanism of miRNA on p53 dynamics in p53-MDM2-miRNA model network incorporating reactive oxygen species (ROS) is studied. The study shows that miRNA drives p53 dynamics at various states, namely, stabilized states and oscillating states (damped and sustain oscillation). We found the co-existence of these states within certain range of the concentartion level of miRNA in the system. This co-existence in p53 dynamics is the signature of the system's survival at various states, normal, activated and apoptosis driven by a constant concentration of miRNA.