2014/09/03 by Gurumayum Reenaroy Devi, Md. Jahoor Alam, Devi, Gurumayum Reenaroy +6
Biochemistry, Genetics and Molecular Biology · Engineering · Physics and Astronomy · #FOS: Biological sciences #Gene Regulatory Network Analysis #Molecular Communication and Nanonetworks #Molecular Networks (q-bio.MN) #q-bio.MN #stochastic dynamics and bifurcation
paper · pdf · doi:10.48550/arxiv.1409.1944
arxiv created 2014/09/03 · openalex publication_date 2014/09/03 · arxiv updated 2014/09/09 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
We study the temporal and the synchronous behaviours in p53-Mdm2 regulatory network due to the interaction of its complex network components with the nitric oxide molecule. In single cell process, increase in nitric oxide concentration gives rise the transition to various p53 temporal behaviours, namely fixed point oscillation, damped oscillation and sustain oscillation indicating stability, weakly activated and strongly activated states. The noise in stochastic system is found to help to reach these states much faster as compared to deterministic case which is evident from permutation entropy dynamics. In coupled system with nitric oxide as diffusively coupling molecule, we found nitric oxide as strong coupling molecule within a certain range of coupling strength εbeyond which it become weak synchronizing agent. We study these effects by using correlation like synchronization indicator γobtained from permutation entropies of the coupled system, and found five important regimes in (ε-γ) phase diagram, indicating desynchronized, transition, strongly synchronized, moderately synchronized and weakly synchronized regimes respectively. We claim that there is the competition between the toxicity and the synchronizing role of nitric oxide that lead the cell in different stressed conditions.