2015/04/20 by Md. Jahoor Alam, Alam, Md. Jahoor, Eyad Al-Shammari +4
Biochemistry, Genetics and Molecular Biology · Medicine · #Cancer-related Molecular Pathways #FOS: Biological sciences #Molecular Networks (q-bio.MN) #Protein Degradation and Inhibitors #Retinoids in leukemia and cellular processes #q-bio.MN
paper · pdf · doi:10.48550/arxiv.1504.05084
arxiv created 2015/04/20 · openalex publication_date 2015/04/20 · arxiv updated 2015/04/21 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
Recent studies suggest that PML (Promyelocytic Leukemia) suppresses p53 protein degradation by inhibiting MDM2 protein in the nucleus [1], and regulates a number of biological functions [2]. We modeled a PML-MDM2-p53 regulatory network by integrating p53-MDM2 autoregulatory model [3] and related PML pathways. We found that p53 dynamics switched at various dynamical states induced by PML which corresponds to different cellular states. Our results show clear transitions among the stabilized, damped and sustain states under different stress conditions induced by PML in the system. These states in p53 dynamics is the signature of existence of various cellular states and the phase transition like behaviour of these states involve various biological significance.