2013/10/10 by Peter Beemiller, Matthew F. Krummel · 1 citation
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · Medicine · #Actin #Actin cytoskeleton #Actin remodeling #Actin remodeling of neurons #Biology #Cell #Cell Adhesion Molecules Research #Cell biology #Cellular Mechanics and Interactions #Cytoplasm #Cytoskeleton #Genetics #Immune system #Immunological synapse #Immunology #Profilin #Signal transduction #T cell #T-cell and B-cell Immunology #T-cell receptor
paper · doi:10.1111/imr.12120
openalex publication_date 2013/10/10 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01
The actin cytoskeleton plays essential roles in modulating T-cell activation. Most models of T-cell receptor (TCR) triggering signalosome assembly and immune synapse formation invoke actin-dependent mechanisms. As T cells are constitutively motile cells, TCR triggering and signaling occur against a cytoskeletal backdrop that is constantly remodeling. While the interplay between actin dynamics and TCR signaling have been the focus of research for many years, much of the work in T cells has considered actin largely for its 'scaffolding' function. We examine the roles of the actin cytoskeleton in TCR signaling and immune synapse formation with an emphasis on how poroelasticity, an ensemble feature of actin dynamics with the cytosol, relates to how T cells respond to stimulation.