Virus interference. I. The interferon

1957/09/12 by Alick Isaacs, J. Lindenmann · 31 citations
Chemistry · Medicine · #Biochemistry #Biology #Chemistry #Incubation #Incubation period #Influenza Virus Research Studies #Interference (communication) #Interferon #Membrane #Microbiology #Viral Interference #Viral replication #Virology #Virus

paper · doi:10.1098/rspb.1957.0048

openalex publication_date 1957/09/12 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/05

Abstract

Abstract During a study of the interference produced by heat-inactivated influenza virus with the growth of live virus in fragments of chick chorio-allantoic membrane it was found that following incubation of heated virus with membrane a new factor was released. This factor, recognized by its ability to induce interference in fresh pieces of chorio-allantoic membrane, was called interferon. Following a lag phase interferon was first detected in the membranes after 3 h incubation and thereafter it was released into the surrounding fluid.

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