The Interferons: 50 Years after Their Discovery, There Is Much More to Learn

2007/05/15 by Sidney Pestka · 2 citations
Medicine · Immunology and Microbiology · Biochemistry, Genetics and Molecular Biology · #Cytokine Signaling Pathways and Interactions #interferon and immune responses #Protein Tyrosine Phosphatases

paper · pdf · doi:10.1074/jbc.r700004200

openalex publication_date 2007/05/15 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

The interferons (IFNs) and their receptors represent a subset of the class 2 alpha-helical cytokines that have been in chordates for millions of years. This brief review focuses on the discovery and purification of interferons, cloning of human IFN-alpha and IFN-beta, interferon receptors, activities and therapeutic uses of interferons, and the side effects of interferons.

Citations

• Virus interference. I. The interferon

Cited by

• Interferons and viral infections
• Interferon [wikipedia]

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