1993/05/01 by C. DACOU‐VOUTETAKIS, Catherine Dacou‐Voutetakis, N. KARIDIS +1 · 2 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Agonist #Central precocious puberty #Congenital adrenal hyperplasia #Endocrinology #Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities #Hormonal Regulation and Hypertension #Hormone #Internal medicine #Medicine #Precocious puberty #Receptor #Sexual Differentiation and Disorders
paper · doi:10.1111/j.1749-6632.1993.tb43873.x
openalex publication_date 1993/05/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
Eight children with congenital adrenal hyperplasia and late initiation of corticosteroid treatment are included in the present study. Four of them received LHRHa treatment for the arrest of central precocious puberty, while the other four served as controls. The administration of LHRHa was effective in arresting the manifestations of puberty. The final height in the LHRHa-treated group was 158.2 +/- 7.3 cm (SDS -1.1 +/- 0.5) and did not differ from the target height of 158.9 +/- 6.5 cm (SDS -1.1 +/- 0.2), while the final height in the controls was 153 +/- 11 cm, a value significantly lower than their target height of 164.5 +/- 8.3 (SDS -0.6 +/- 0.7) with p < 0.05. The data showed that LHRHa is effective in arresting central precocious puberty and appears to improve final height, bringing it closer to that expected from the genetic potentials.