Involvement of calcium channels Orai3 in the chemoresistance to cisplatin in non-small cell lung cancer (NSCLC)

2023/07/18 by Rédoane Daoudi, Daoudi, Rédoane
Neuroscience · #FOS: Biological sciences #Ion Channels and Receptors #Subcellular Processes (q-bio.SC) #Tissues and Organs (q-bio.TO)

paper · pdf · doi:10.48550/arxiv.2307.10289

openalex publication_date 2023/07/18 · openalex created_date 2023/07/22 · openalex updated_date 2026/07/28

Abstract

This is the second part of the previous review. In the previous review we suspected that Orai3 channels were involved in lung cancer and more precisely in several cancers. Here we confirm that calcium dysregulation is important for cancer development. in this paper we show that Orai3 is an upstream activator of AKT and we prove that AKT is involved in chemoresistance in NSCLC.

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