Role of Orai‐family channels in the activation and regulation of transcriptional activity

2023/03/23 by Joel Nieto‐Felipe, Alvaro Macias‐Diaz, Alvaro Macias‐Díaz +10 · 7 citations
Neuroscience · Medicine · Pharmacology, Toxicology and Pharmaceutics · #Ion Channels and Receptors #Phytochemicals and Antioxidant Activities #Bioactive Compounds and Antitumor Agents

paper · pdf · doi:10.1002/jcp.30971

Abstract

Abstract Store operated Ca 2+ entry (SOCE) is a cornerstone for the maintenance of intracellular Ca 2+ homeostasis and the regulation of a variety of cellular functions. SOCE is mediated by STIM and Orai proteins following the activation of inositol 1,4,5‐trisphosphate receptors. Then, a reduction of the endoplasmic reticulum intraluminal Ca 2+ concentration is sensed by STIM proteins, which undergo a conformational change and activate plasma membrane Ca 2+ channels comprised by Orai proteins. STIM1/Orai‐mediated Ca 2+ signals are finely regulated and modulate the activity of different transcription factors, including certain isoforms of the nuclear factor of activated T‐cells, the cAMP‐response element binding protein, the nuclear factor κ‐light chain‐enhancer of activated B cells, c‐fos, and c‐myc. These transcription factors associate SOCE with a plethora of signaling events and cellular functions. Here we provide an overview of the current knowledge about the role of Orai channels in the regulation of transcription factors through Ca 2+ ‐dependent signaling pathways.

Citations

• STIM‐1 and ORAI‐1 channel mediate angiotensin‐II‐induced expression of Egr‐1 in vascular smooth muscle cells

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