- Resistance to trimethoprim/sulfamethoxazole and Tropheryma whipplei
2009/04/07 by Florence Fenollar, Jean‐Marc Rolain, Jean-Marc Rolain +7 · 70 citations
Medicine · #Antibiotics #Biology #Dihydropteroate synthase #Disease #Immunology #Internal medicine #Medicine #Microbiology #Pyrimethamine #Sulfamethoxazole #Trimethoprim #Tropheryma whipplei #Virology #Whipple Disease #Whipple's Disease and Interleukins #Whipple's disease
- Drug design by machine learning: the use of inductive logic programming to model the structure-activity relationships of trimethoprim analogues binding to dihydrofolate reductase.
1992/12/01 by Ross D. King, Stephen Muggleton, Richard A. Lewis +1 · 221 citations
Computer Science · Pharmacology, Toxicology and Pharmaceutics · Chemistry · Mathematics · #Computational Drug Discovery Methods #Pharmacogenetics and Drug Metabolism #Analytical Chemistry and Chromatography #Dihydrofolate reductase #Inductive logic programming #Flexibility (engineering) #Computer science #Quantitative structure–activity relationship #Machine learning #Trimethoprim #Artificial intelligence #Computational biology #Chemistry #Stereochemistry #Theoretical computer science #Biology #Biochemistry #Mathematics #Enzyme