PP9, a steroidal saponin, induces G2/M arrest and apoptosis in human colorectal cancer cells by inhibiting the PI3K/Akt/GSK3β pathway

2020/08/30 by Minna Yao, Ruili Li, Zhifu Yang +9 · 40 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Medicine · #Apoptosis #Biochemistry #Cancer #Cancer research #Cell cycle #Cell cycle checkpoint #Cell death mechanisms and regulation #Chemistry #Colorectal cancer #Cyclin B1 #Cyclin-dependent kinase 1 #Downregulation and upregulation #Internal medicine #LY294002 #Medicine #Natural product bioactivities and synthesis #PI3K/AKT/mTOR pathway #Phytochemical Studies and Bioactivities #Protein kinase B

paper · doi:10.1016/j.cbi.2020.109246

published in Chemico-Biological Interactions 331, 109246 (Elsevier BV)

openalex publication_date 2020/08/30 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28

Citations

• Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

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