Analytical equivalence between standard and refined lethality neutralization protocols for snake antivenoms

2026/03/07 by Gabriela Solano, Gina Durán, Mauren Villalta +4
Biochemistry, Genetics and Molecular Biology · Earth and Planetary Sciences · #Venomous Animal Envenomation and Studies #Marine Invertebrate Physiology and Ecology #Ion channel regulation and function

paper · doi:10.1016/j.toxicon.2026.109058

Citations

• The lethality test used for estimating the potency of antivenoms against Bothrops asper snake venom: Pathophysiological mechanisms, prophylactic analgesia, and a surrogate in vitro assay
• Reducing time in lethality assay (LD50) for Bothrops jararaca and Crotalus durissus terrificus venoms and lethality neutralizing assay (ED50) for their respective antivenoms: A 3Rs-based retrospective data validation
• Complying with ARRIVE 2.0: Reporting essentials for animal models of envenoming therapeutic efficacy testing