Reduced sulfur mustard-induced skin toxicity in cyclooxygenase-2 knockout and celecoxib-treated mice

2004/05/29 by Uri Wormser, Robert Langenbach, Shyamal D. Peddada +4 · 49 citations
Chemistry · Medicine · #Biochemistry #Celecoxib #Chemistry #Cyclooxygenase #Edema #Enzyme #Inflammation #Inflammatory mediators and NSAID effects #Internal medicine #Medicine #Necrosis #Pharmacology #Sulfur mustard #Synthesis and Biological Evaluation #Synthesis and biological activity #Toxicity

paper · doi:10.1016/j.taap.2004.03.013

published in Toxicology and Applied Pharmacology 200(1), 40-47 (Elsevier BV)

openalex publication_date 2004/05/29 · openalex created_date 2025/10/10 · openalex updated_date 2026/06/21

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• Role of MAP kinases in regulating expression of antioxidants and inflammatory mediators in mouse keratinocytes following exposure to the half mustard, 2-chloroethyl ethyl sulfide. [europepmc]
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• Functional and inflammatory alterations in the lung following exposure of rats to nitrogen mustard. [europepmc]
• Role of TNFR1 in lung injury and altered lung function induced by the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide. [europepmc]
• Structural changes in the skin of hairless mice following exposure to sulfur mustard correlate with inflammation and DNA damage. [europepmc]
• Sulfur mustard analog, 2-chloroethyl ethyl sulfide-induced skin injury involves DNA damage and induction of inflammatory mediators, in part via oxidative stress, in SKH-1 hairless mouse skin. [europepmc]
• Role of reactive nitrogen species generated via inducible nitric oxide synthase in vesicant-induced lung injury, inflammation and altered lung functioning. [europepmc]
• Therapeutic potential of a non-steroidal bifunctional anti-inflammatory and anti-cholinergic agent against skin injury induced by sulfur mustard. [europepmc]
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• Mitigation of nitrogen mustard mediated skin injury by a novel indomethacin bifunctional prodrug. [europepmc]
• The therapeutic effects of bone marrow-derived mesenchymal stromal cells in the acute lung injury induced by sulfur mustard. [europepmc]
• Antioxidant/stress response in mouse epidermis following exposure to nitrogen mustard. [europepmc]
• Vitamin D3 ameliorates nitrogen mustard-induced cutaneous inflammation by inactivating the NLRP3 inflammasome through the SIRT3-SOD2-mtROS signaling pathway. [europepmc]
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