Association of the OPRM1 and COMT genes’ polymorphisms with the efficacy of morphine in Tunisian cancer patients: Impact of the high genetic heterogeneity in Tunisia?

2016/05/18 by Imen Chatti, Isabelle Creveaux, Jean-Baptiste Woillard +10 · 13 citations
Medicine · Neuroscience · #Biology #Cancer #Cancer pain #Cancer, Stress, Anesthesia, and Immune Response #Catechol-O-methyl transferase #Gene #Genetic association #Genetics #Genotype #Gynecology #Haplotype #Internal medicine #Medicine #Morphine #Neuropeptides and Animal Physiology #Oncology #Opioid #Pain Management and Opioid Use #Receptor #SNP #Single-nucleotide polymorphism #rs4680

paper · doi:10.1016/j.therap.2016.04.004

published in Therapies 71(5), 507-513 (Elsevier BV)

openalex publication_date 2016/05/18 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/29

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• Opioid Addiction and Opioid Receptor Dimerization: Structural Modeling of the OPRD1 and OPRM1 Heterodimer and Its Signaling Pathways. [europepmc]
• The effects of OPRM1 118A>G on methadone response in pain management in advanced cancer at end of life. [europepmc]