New Heterocyclic Inputs for the Povarov Multicomponent Reaction

2011/06/09 by Rodolfo Lavilla, Esther Vicente-García, Esther Vicente‐García +1
Chemistry · #Multicomponent Synthesis of Heterocycles #Synthesis of heterocyclic compounds #Synthesis and biological activity

paper · doi:10.1055/s-0030-1260062

Abstract

Oxa-, thia- and imidazolones are reactive inputs as electron-rich olefin components in Povarov reactions. On interaction with anilines and aldehydes, these substrates afford the corresponding multicomponent adducts in a regioselective manner. Intramolecular processes are also explored. Post-condensation oxidation provides convenient access to a variety of fused quinoline derivatives.

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