2022/03/10 by Ângelo de Fátima, Sergio Antonio Fernandes, Sérgio Antônio Fernandes +2
Chemistry · Biochemistry, Genetics and Molecular Biology · #Asymmetric Synthesis and Catalysis #Chemical synthesis and alkaloids #Synthesis and Biological Activity
paper · doi:10.1055/a-1794-8355
Abstract The multicomponent Povarov reaction represents a powerful approach for the construction of substances containing N-heterocyclic frameworks. By using the Povarov reaction, in addition to accessing tetrahydroquinolines, quinolines and julolidines in a single step, it is possible to form the following new bonds: two Csp 3–Csp 3 and one Csp 3–Nsp 3, two Csp 2–Csp 2 and one Csp 2–Nsp 2, and four Csp 3–Csp 3 and two Csp 3–Nsp 1, respectively. This short review discusses the main features of the Povarov reaction, including its mechanism, the reaction scope by employing different catalysts and substrates, as well as stereoselective versions. 1 Introduction 2 Mechanism of the Povarov Reaction 3 Tetrahydroquinolines 4 Quinolines 5 Julolidines 6 Concluding Remarks