Synthesis of Borylated Hydrazino Acid Derivatives

2021/05/31 by Andrei K. Yudin, Chieh-Hung Tien, Chieh‐Hung Tien +2
Chemistry · #Organoboron and organosilicon chemistry #Catalytic Cross-Coupling Reactions #Radical Photochemical Reactions

paper · doi:10.1055/s-0040-1706046

Abstract

Abstract α-Boryl-α-hydrazinoacetic acid is a highly functionalized boron-containing building block that can be easily accessed from readily available α-borylacetaldehyde. The hydrazine motif can be converted into a variety of α-borylated azoles and diazines in a straightforward protocol. Furthermore, the carboxy group can be derivatized to afford novel organoboron compounds that should find applications in various cross-coupling transformations.

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