Stereoselective Synthesis of α‐Azido Esters and α‐Amino Acid Derivatives via Matteson Homologation of Boronic Esters

2024/07/11 by Alexander Horn, Emanuel Papadopoulos, Thorsten Kinsinger +5
Biochemistry, Genetics and Molecular Biology · Chemistry · #Chemical Synthesis and Analysis #Catalytic C–H Functionalization Methods #Click Chemistry and Applications

paper · pdf · doi:10.1002/zaac.202400113

Abstract

Abstract Matteson homologation with sodium azide in DMF proved to be an excellent highly stereoselective tool for the synthesis of complex α‐azido and α‐amino acids. Both enantiomers are easily accessible via the choice of the chiral boronic ester auxiliary.

Citations

• A Complementary Toolbox of Iterative Methods for the Stereoselective Synthesis of Heteroatom-Rich Motives from C1-Building Blocks

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