2020/12/19 by Nicola Vassena, Vassena, Nicola
Biochemistry, Genetics and Molecular Biology · #34D10 #92C42 #93B35 #Dynamical Systems (math.DS) #FOS: Biological sciences #FOS: Mathematics #Gene Regulatory Network Analysis #Microbial Metabolic Engineering and Bioproduction #Molecular Networks (q-bio.MN) #Protein Structure and Dynamics
paper · pdf · doi:10.48550/arxiv.2012.10687
openalex publication_date 2020/12/19 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
Sensitivity studies the network response to perturbations. We consider local perturbations of the concentrations of metabolites at an equilibrium. We investigate the responses in the network, both of the metabolite concentrations and of the reaction fluxes. Our approach is purely qualitative, rather than quantitative. In fact, our analysis is based, solely, on the stoichiometry of the reaction network and we do not require any quantitative information on the reaction rates. Instead, the description is done only in algebraic terms, and the only data required is the network structure. Biological applications include metabolic control and network reconstruction.