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Blood Vessels: Depiction at Phase-Contrast X-ray Imaging without Contrast Agents in the Mouse and Rat—Feasibility Study

2000/11/01 by Atsushi Momose, Tohoru Takeda, Yuji Itai · 2 citations
Physics and Astronomy · #Advanced X-ray Imaging Techniques #X-ray Spectroscopy and Fluorescence Analysis #Laser-Plasma Interactions and Diagnostics

paper · doi:10.1148/radiology.217.2.r00oc14593

Abstract

The ability of phase-contrast x-ray imaging to depict blood vessels without contrast agents was tested by observing livers of a mouse and a rat with synchrotron x rays. Livers were excised by tying arteries and veins to prevent blood from flowing out of the liver. An x-ray interferometer was used to obtain x-ray phase contrast. With the technique of phase-shifting x-ray interferometry, the image mapping x-ray phase shift caused by a liver was measured. The x-ray phase shift caused by blood was substantially different from that caused by other soft tissues; consequently, trees of blood vessels were revealed on the image. Vessels with diameter smaller than 0.1 mm were recognized. This result allows new possibilities for investigation of the vascular system.

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