2012/12/20 by Thomas Weber, Weber, Thomas, Florian Bayer +19 · 1 citation
Physics and Astronomy · #Advanced X-ray Imaging Techniques #Biological Physics (physics.bio-ph) #FOS: Physical sciences #Laser-Plasma Interactions and Diagnostics #Medical Physics (physics.med-ph) #X-ray Spectroscopy and Fluorescence Analysis
paper · pdf · doi:10.48550/arxiv.1212.5031
openalex publication_date 2012/12/20 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28
Purpose: Grating-based X-ray phase-contrast imaging is a promising modality increasing the soft tissue contrast in medical imaging. In this work, the signature of lung tissue in X-ray grating-based physe-contrast imaging is investigated. Methods: We used a Talbot-Lau interferometer for our investigations of two C57BL/6 mice. Both underwent projection imaging and computed tomography. Results: The results show that the three images obtained by X-ray phase-contrast imaging show complementary anatomical structures. Especially the dark field image allows a more-exact determination of the position of the lung in the chest cavity. Conclusion: Due to its sensitivity to granular structures, the dark field image may be used for the diagnosis of lung diseases in earlier stages or without a CT scan. Furthermore, X-ray phase-contrast imaging may also have great potential in the application of animal laboratory sciences to reduce the number of required animals used in long-term translational, toxicity, and regenerative medicine studies.