Sequence-defined structural transitions by calcium-responsive proteins

2024/01/01 by Marina P. Chang, Winnie Huang, Gatha M. Shambharkar +2 · 1 voice · 3 citations
Biochemistry, Genetics and Molecular Biology · #Bacterial Genetics and Biotechnology #Protein Structure and Dynamics #RNA and protein synthesis mechanisms

paper · pdf · doi:10.1039/d4py00907j

openalex publication_date 2024/01/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

Recombinant protein engineering accelerated the synthesis of sequence-defined, calcium-responsive biopolymers. A mutation panel of repeats-in-toxin (RTX) proteins revealed sequence-dependent disorder, calcium sensitivity, and structural transitions.

Citations

• The Hill equation and the origin of quantitative pharmacology

Cited by

• Biomolecular Actuators for Soft Robots
• Ion-selective conformational stabilization of a disordered repeats-in-toxin protein domain. [europepmc]
• Rare Earth Element-Induced Condensation of the Block V of the Repeats-in-Toxin Domain from CyaA from Bordetella pertussis for Separations. [europepmc]

Discussions

• 1st post in a new space seems like a good spot to feature the 1st project by the lab's 1st PhD student! We set out to engineer calcium-responsive proteins as muscle-mimetic materials and discovered so [bsky, 34 points, 1 comments]

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