The Hill equation and the origin of quantitative pharmacology

2012/03/30 by Rudolf Gesztelyi, Judit Zsuga, Ádám Kemény‐Beke +7 · 33 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · Computer Science · #Receptor Mechanisms and Signaling #Analytical Chemistry and Chromatography #Computational Drug Discovery Methods

paper · doi:10.1007/s00407-012-0098-5

Cited by

• Sequence-defined structural transitions by calcium-responsive proteins
• How boundary conditions govern lacustrine delta growth and slope curvature: Insights from numerical modelling
• Integrating Expert ODEs into Neural ODEs: Pharmacology and Disease Progression
• Identifiability, Sensitivity, and Genetic Algorithms in Bacterial Biofilm Selection Models
• Simulation-based inference using splitting schemes for partially observed diffusions in chemical reaction networks
• First derivatives at the optimum analysis (fdao): An approach to estimate the uncertainty in nonlinear regression involving stochastically independent variables
• Light-Driven Lithium Extraction from Mixtures of Alkali Cations Using an Azobipyridine Ligand
• Implications of source-sink feedbacks for modelling tree carbon assimilation and growth
• Equilibrium distributions of simple biochemical reaction systems for time-scale separation in stochastic reaction networks. [europepmc]
• Homo-FRET Based Biosensors and Their Application to Multiplexed Imaging of Signalling Events in Live Cells. [europepmc]
• Mathematical Model of Innate and Adaptive Immunity of Sepsis: A Modeling and Simulation Study of Infectious Disease. [europepmc]
• A mathematical model of mechanotransduction reveals how mechanical memory regulates mesenchymal stem cell fate decisions. [europepmc]
• Methodical Challenges and a Possible Resolution in the Assessment of Receptor Reserve for Adenosine, an Agonist with Short Half-Life. [europepmc]
• Fenugreek (Trigonella Foenum-Graecum) Seed Flour and Diosgenin Preserve Endothelium-Dependent Arterial Relaxation in a Rat Model of Early-Stage Metabolic Syndrome. [europepmc]
• A Receptor Model With Binding Affinity, Activation Efficacy, and Signal Amplification Parameters for Complex Fractional Response Versus Occupancy Data. [europepmc]
• Multi-scale modeling of drug binding kinetics to predict drug efficacy. [europepmc]
• Drug-target binding quantitatively predicts optimal antibiotic dose levels in quinolones. [europepmc]
• A Comprehensive Spectroscopic Analysis of the Ibuprofen Binding with Human Serum Albumin, Part I. [europepmc]
• High-Sensitivity High-Throughput Detection of Nucleic Acid Targets on Metasurface Fluorescence Biosensors. [europepmc]
• Infection, inflammation and intervention: mechanistic modelling of epithelial cells in COVID-19. [europepmc]
• Detection of an IL-6 Biomarker Using a GFET Platform Developed with a Facile Organic Solvent-Free Aptamer Immobilization Approach. [europepmc]
• Seaweed cellulose scaffolds derived from green macroalgae for tissue engineering. [europepmc]
• Surface Plasmon Resonance Assay for Label-Free and Selective Detection of HIV-1 p24 Protein. [europepmc]
• Effects of the sigma-1 receptor agonist blarcamesine in a murine model of fragile X syndrome: neurobehavioral phenotypes and receptor occupancy. [europepmc]
• Ruthenium Half-Sandwich Type Complexes with Bidentate Monosaccharide Ligands Show Antineoplastic Activity in Ovarian Cancer Cell Models through Reactive Oxygen Species Production. [europepmc]
• Serine acetyltransferase from Neisseria gonorrhoeae; structural and biochemical basis of inhibition. [europepmc]
• Binding of AP endonuclease-1 to G-quadruplex DNA depends on the N-terminal domain, Mg 2+ and ionic strength. [europepmc]
• Reactive Oxygen Species Production Is Responsible for Antineoplastic Activity of Osmium, Ruthenium, Iridium and Rhodium Half-Sandwich Type Complexes with Bidentate Glycosyl Heterocyclic Ligands in Various Cancer Cell Models. [europepmc]
• Improved calibration of electrochemical aptamer-based sensors. [europepmc]
• Multiparametric quantitative phase imaging for real-time, single cell, drug screening in breast cancer. [europepmc]
• Differential pulse voltammetry and chronoamperometry as analytical tools for epinephrine detection using a tyrosinase-based electrochemical biosensor. [europepmc]
• Deconvolution of clinical variance in CAR-T cell pharmacology and response. [europepmc]
• Specificity, synergy, and mechanisms of splice-modifying drugs. [europepmc]