Accurate Coarse-Grained Modeling of Red Blood Cells

2008/09/12 by Igor V. Pivkin, George Em Karniadakis · 5 citations
Medicine · Chemical Engineering · Biochemistry, Genetics and Molecular Biology · #Blood properties and coagulation #Rheology and Fluid Dynamics Studies #Lipid Membrane Structure and Behavior

paper · doi:10.1103/physrevlett.101.118105

Abstract

We develop a systematic coarse-graining procedure for modeling red blood cells (RBCs) using arguments based on mean-field theory. The three-dimensional RBC membrane model takes into account the bending energy, in-plane shear energy, and constraints of fixed surface area and fixed enclosed volume. The coarse-graining procedure is general, it can be used for arbitrary level of coarse-graining and does not employ any fitting parameters. The sensitivity of the coarse-grained model is investigated and its behavior is validated against available experimental data and in dissipative particle dynamics (DPD) simulations of RBCs in capillary and shear flows.

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